PREPARATION METHOD FOR 4-(HYDROXYMETHYLPHOSPHINYL)-2-OXOBUTYRIC ACID

World Intellectual Property Organization Patent

APP PUB NO WO-2024051120-A1
SERIAL NO

PCTCN2023079814

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Abstract

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A preparation method for 4-(hydroxymethylphosphinyl)-2-oxobutyric acid, comprising the following steps: a) mixing 3-chloropropionyl chloride, a first solvent, trimethylsilyl cyanide, and a cyanide salt, carrying out a substitution reaction to obtain a feed liquid containing 4-chloro-2-oxobutyronitrile, and then carrying out reduced pressure distillation and separation to obtain a 4-chloro-2-oxobutyronitrile intermediate; b) carrying out Arbuzov reaction on the obtained 4-chloro-2-oxobutyronitrile intermediate and methyl phosphonite in a second solvent in the presence of cuprous iodide to obtain a feed liquid of (3-cyano-3-oxopropyl)methyl phosphinate, and purifying to obtain a crude product of (3-cyano-3-oxopropyl)methyl phosphinate; and c) mixing the obtained crude product of (3-cyano-3-oxopropyl)methyl phosphinate with hydrochloric acid, carrying out a hydrolysis reaction, and then carrying out purification treatment to obtain 4-(hydroxymethylphosphinyl)-2-oxobutyric acid. According to the preparation method, 4-(hydroxymethylphosphinyl)-2-oxobutyric acid can be obtained with high yield. The reaction conditions are mild, the operation is simple and convenient, the production cost is low, and industrialization is easy to realize.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO LTDCN311600 11TH FLOOR REFORM MONTHLY REPORT BUILDING ZHONGHE MIDDLE ROAD HANGZHOU CITY ZHEJIANG PROVINCE CHINA HANGZHOU CITY ZHEJIANG PROVINCE 311600

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Inventor(s)

Inventor Name Address
QIN LONG 中国浙江省杭州市建德市江滨中路新安大厦1号 ZHEJIANG 311600 311600
ZHOU SHUGUANG 中国浙江省杭州市建德市江滨中路新安大厦1号 ZHEJIANG 311600 311600
WANG PING 中国北京市北京经济技术开发区地泽路9号 BEIJING 100176 100176
WU JIANPING 中国浙江省杭州市西湖区余杭塘路866号 ZHEJIANG 310058 310058
WANG LINLIN 中国广东省深圳市南山区科技园区南区粤兴三道6号南京大学深圳产学研大楼A座6楼 GUANGDONG 518057 518057
YANG LIRONG 中国浙江省杭州市西湖区余杭塘路866号 ZHEJIANG 310058 310058
ZHOU HAISHENG 中国浙江省杭州市西湖区余杭塘路866号 ZHEJIANG 310058 310058
ZHAN BO 中国山东省青岛市崂山区科苑纬一路1号创新园一期D1座2206 SHANDONG 266100 266100
YU SHENLUAN 中国浙江省杭州市建德市江滨中路新安大厦1号 ZHEJIANG 311600 311600

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