IMPROVED SYNTHESIS FOR BORYLATED AMINO ACID COMPOSITIONS COMPRISING TC220 AND TC221 FOR USE IN BORON NEUTRON CAPTURE THERAPY AND METHODS THEREOF

World Intellectual Property Organization Patent

APP PUB NO WO-2025038946-A1
SERIAL NO

PCTUS2024042717

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Abstract

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Borylated Amino Acid compositions comprising tyrosine derivatives TC220 and TC221 and improved methods of making TC220 and TC221 are disclosed herein. Consequently, the TC220 and/or TC221 can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.

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Patent Owner(s)

Patent OwnerAddress
TAE LIFE SCIENCES LLCUSIRVINE CA

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Inventor(s)

Inventor Name Address
TORGOV MICHAEL Y REDONDO BEACH CA
ZHICHKIN PAUL 45 THORNDALE ROAD SLINGERLANDS NY 12159 12159
MARTIN TIOGA 1871 GREENFIELD AVENUE UNIT 402 LOS ANGELES CA 90025 90025

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