A MICROBIAL ELECTROCHEMICAL TECHNOLOGY TO DETECT AND DEGRADE ORGANOPHOSPHATE PESTICIDES

World Intellectual Property Organization Patent

APP PUB NO WO-2023044345-A1
SERIAL NO

PCTUS2022076432

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Abstract

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Provided herein are recombinant microbial cells displaying on their surface a non-native protein capable of degrading an organophosphate, wherein the recombinant microbial cell has inhibited replication, as well as recombinant microbial cells engineered to be capable of expressing a non-native transcription factor that activates a non-native promoter in response to an organophosphate degradation product, wherein the non-native promoter is operatively linked to a nucleic acid encoding a reporter protein, wherein activity of the reporter protein can be detected, and their use for degrading organophosphates and detecting organophosphate degradation products.

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Patent Owner(s)

Patent OwnerAddress
MASSACHUSETTS INST TECHNOLOGYUSMASSACHUSETTS

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Inventor(s)

Inventor Name Address
REYNOLDS ERIN WESTBOROUGH MA
FURST ARIEL CAMBRIDGE MA
AHLMARK RACHEL LANSDALE PA
KARBELKAR AMRUTA WHITE RIVER JUNCTION VT

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