Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid
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United States of America Patent
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-
Jan 13, 1981
Grant Date -
N/A
app pub date -
Jun 11, 1979
filing date -
Jun 11, 1979
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.
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