Peptides whose uptake in cells is controllable

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United States of America Patent

PATENT NO 9682151
SERIAL NO

13384591

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Abstract

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Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aguilera, Todd San Diego, US 4 73
Jiang, Tao San Diego, US 502 4116
Nguyen, Quyen Del Mar, US 21 264
Olson, Emilia Seattle, US 5 61
Tsien, Roger La Jolla, US 14 197

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