Use of nitrite salts for the treatment of cardiovascular conditions

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United States of America Patent

PATENT NO 9675637
SERIAL NO

10563683

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Abstract

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It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

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Patent Owner(s)

  • LOMA LINDA UNIVERSITY;BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE;THE UAB RESEARCH FOUNDATION;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;WAKE FOREST UNIVERSITY HEALTH SCIENCES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cannon,, III Richard O Potomac, US 5 40
Gladwin, Mark T Washington, US 21 175
Hunter, Christian J Boston, US 5 95
Kim-Shapiro, Daniel B Winston-Salem, US 12 104
Lefer, David J Bronx, US 9 94
Oldfield, Edward H Philomont, US 8 394
Patel, Rakesh P Birmingham, US 8 96
Pluta, Ryszard Bethesda, US 1 55
Power, Gordon G Redlands, US 5 95
Schechter, Alan N Bethesda, US 6 101

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