TREATMENT OF CHRONIC PAIN WITH ZINC FINGER PROTEINS
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United States of America Patent
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Issued Date -
Aug 27, 2009
app pub date -
Feb 6, 2009
filing date -
Feb 8, 2008
priority date (Note) -
Abandoned
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Abstract
A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating chronic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having chronic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing chronic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., Nav1.8) can be repressed.
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