Adeno-associated virus variants and methods of use thereof

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United States of America Patent

PATENT NO 10883117
APP PUB NO 20180066285A1
SERIAL NO

15556986

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Abstract

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The present disclosure provides recombinant adeno-associated virus (rAAV) virions comprising a variant AAV capsid protein, e.g., an AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence. An rAAV virion of the present disclosure can exhibit greater infectivity of a target cell. The present disclosure also provides methods of delivering a gene product to a target cell in an individual by administering to the individual an rAAV of the present disclosure. The present disclosure also provides methods of generating rAAV virions that have a variant AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Holmes, Ian H Berkeley, US 4 25
Ojala, David S Berkeley, US 3 18
Santiago-Ortiz, Jorge Berkeley, US 3 18
Schaffer, David V Danville, US 60 1008
Weinstein, John Berkeley, US 4 27
Westesson, Oscar Berkeley, US 8 18

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