METHODS OF DETECTING CELL-FREE DNA IN BIOLOGICAL SAMPLES
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United States of America
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Feb 13, 2020
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Apr 5, 2018
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Apr 5, 2018
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Abstract
The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.
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