Use of polyols for improving the introduction of genetic material into cells
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United States of America Patent
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Sep 3, 1996
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app pub date -
Sep 30, 1994
filing date -
Sep 30, 1994
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Abstract
A process for introducing an expression vehicle (e.g., plasmids, retroviral vectors, adenoviral vectors) into cells, which comprises contacting the cells with the expression vehicle and a polyol. The polyol may be a polyoxalkylene block copolymer, such as a polyoxypropylene-polyoxyethylene block copolymer. The use of the polyol provides for greater efficiency of transduction of the expression vehicle.
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