Fermentative preparation process for and crystal forms of cytostatics

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United States of America Patent

PATENT NO 6194181
SERIAL NO

09248910

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Abstract

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The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGLICHTSTRASSE 35 BASEL 4056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hofmann, Hans Ettingen, CH 34 452
Kusters, Ernst Eschbach, DE 15 114
Mahnke, Marion Steinen, DE 7 71
Memmert, Klaus Lorrach, DE 8 74
Mutz, Michael Freiburg, DE 53 170
Petersen, Frank Weil am Rhein, DE 10 72
Schupp, Thomas Mohlin, CH 37 341

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