Isolation and use of solid tumor stem cells

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United States of America Patent

PATENT NO 7713710
SERIAL NO

11753191

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Abstract

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A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

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Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF MICHIGANINNOVATION PARTNERSHIPS 1600 HURON PARKWAY 2ND FLOOR ANN ARBOR MI 48109-2590

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Al-Hajj, Muhammad Ann Arbor, US 21 620
Clarke, Michael F Ann Arbor, US 66 3077
Morrison, Sean J Ann Arbor, US 17 543
Wicha, Max S Ann Arbor, US 31 810

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