Assays for resistance to echinocandin-class drugs

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United States of America Patent

PATENT NO 8753819
SERIAL NO

11995966

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Abstract

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Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

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Patent Owner(s)

  • MERCK & CO., INC.;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Douglas, Cameron M Piscataway, US 4 18
Kahn, Jennifer Nielsen East Brunswick, US 2 16
Kelly, Rosemarie Westfield, US 10 47
Parent, Stephen A Belle Mead, US 4 16
Park, Steven Whitestone, US 24 132
Perlin, David S Chappaqua, US 13 21

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