Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof

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United States of America Patent

PATENT NO 9394363
APP PUB NO 20130149313A1
SERIAL NO

13685899

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Abstract

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The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.

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Patent Owner(s)

  • ABBVIE DEUTSCHLAND GMBH & CO KG;ABBVIE INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DiGiammarino, Enrico L Lindenhurst, US 12 130
Ebert, Ulrich Mannheim, DE 33 642
Fox, Gerard B Barrington Hills, US 4 63
Gu, Jijie Shewsbury, US 47 911
Harlan, John E Lake Zurich, US 9 142
Hsieh, Chung-Ming Newton, US 120 1509
Loebbert, Ralf Speyer, DE 5 65
Luo, Feng Arlington Heights, US 16 92
Mueller, Reinhold Schifferstadt, DE 28 396
Nimmrich, Volker Heidelberg, DE 10 84
Schmidt, Martin Bensheim, DE 227 2277
Wu, Zhen Framingham, US 66 318

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