High affinity antibodies to human IL-6 receptor

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United States of America Patent

PATENT NO 9884916
SERIAL NO

15136152

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Abstract

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A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.;REGENERON PHARMACUEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Gang Yorktown Heights, US 891 7739
Fairhurst, Jeanette L White Plains, US 27 1073
Fandl, James P LaGrangeville, US 79 1642
Huang, Tammy T Cross River, US 42 1958
Karow, Margaret Santa Rosa Valley, US 89 1172
Martin, Joel H Putnam Valley, US 71 2454
Papadopoulos, Nicholas J LaGrangeville, US 108 3474
Pobursky, Kevin J Warren, US 20 756
Rafique, Ashique Yonkers, US 24 770
Smith, Eric New York, US 231 3278
Stevens, Sean Del Mar, US 209 3555

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