Carbocyclic thromboxane A.sub.2 analogues
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United States of America Patent
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Apr 7, 1981
Grant Date -
N/A
app pub date -
Oct 24, 1979
filing date -
Oct 24, 1979
priority date (Note) -
Expired
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Abstract
Stable biologically active thromboxane A.sub.2 analogues having the formula: ##STR1## wherein R.sup.1 is OR.sup.3, where R.sup.3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or R.sup.1 is NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are the same or different substituents selected from the group consisting of hydrogen and lower alkyl group; and R.sup.2 is hydrogen or an --OH group. The thromboxane analogues are potent thrombotic agents, useful in cardiovascular treatment.
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