Selective reduction of cysteine residues in IL-17 antibodies

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United States of America

PATENT NO 11292833
APP PUB NO 20170369567A1
SERIAL NO

15538266

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Abstract

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The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AG4056 BASEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Heitzmann, Markus Lörrach, DE 6 15
Winkler, Johann Kiefersfelden, DE 11 84

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