Weakly acidic pH-responsive peptide and liposome containing same

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United States of America Patent

PATENT NO 9526791
APP PUB NO 20150250893A1
SERIAL NO

14430723

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Abstract

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A problem to be solved by the present invention is to provide a peptide compound for producing a drug delivery carrier capable of releasing a target substance in a weakly acidic pH environment. The present invention provides a peptide compound comprising a hydrophilic amino acid block and a hydrophobic amino acid block; [1] the peptide compound containing 24 to 36 amino acids in total; [2] the hydrophilic amino acid block containing 4 to 10 amino acids in total and having an average hydropathy index of −3.0 to −1.0; and [3] the hydrophobic amino acid block containing 20 to 32 amino acids in total, containing one or more His residues, and having an average hydropathy index of 1.0 to 2.5.

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Patent Owner(s)

  • TAIHO PHARMACEUTICAL CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hama, Susumu Otsu, JP 8 55
Kogure, Kentaro Otsu, JP 27 71

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