Cryptic metabolites and method for activating silent biosynthetic gene clusters in diverse microorganisms

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United States of America Patent

PATENT NO 11549950
APP PUB NO 20210041452A1
SERIAL NO

16634388

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Abstract

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Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites. These are then isolated and characterized. Employing the disclosed approach activated production of cryptic glycopeptides from an actinomycete bacterium. The molecules that result, the keratinimicins and keratinicyclins, are metabolites with important structural features. At least two of these, keratinimicins B and C, are highly bioactive against several pathogenic strains. This approach will allow for rapid activation and identification of cryptic metabolites from diverse microorganisms in the future.

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Patent Owner(s)

  • THE TRUSTEES OF PRINCETON UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bushin, Leah Princeton, US 2 0
Davis, Katherine Princeton, US 2 0
Seyedsayamdost, Mohammad R Princeton, US 12 16
Wu, Yihan Princeton, US 7 7
Xu, Fei Princeton, US 164 697

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