Combined preparation of a thiazide diuretic and a loop diuretic
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United States of America Patent
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Sep 10, 2013
Grant Date -
Aug 19, 2010
app pub date -
Jan 14, 2008
filing date -
Jan 12, 2007
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Abstract
The specific molecular basis of the interaction between talin and integrin β3 has been defined. This specific interaction provides a new therapeutic target; agents that can disrupt this specific interaction should be useful therapeutic agents for a number of significant diseases and conditions including inflammation, heart disease, including myocardial infarction, and tumor metastasis. The present invention includes a chimeric peptide that has high affinity for talin, muteins of talin and integrin β3 as well as screening methods for agents that can disrupt the interaction between talin and integrin β3.
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